Effect of manuka honey on biofilm formation
Methicillin-resistant Staphylococcus aureus (MRSA) are among the most important biofilm-forming pathogens responsible for hard-to-treat infections.
Researchers evaluated the effects of manuka honey on the genes essential for staphylococcal biofilm formation from two hospital MRSA strains.
MRSA strains were isolated after 4, 8, 12 and 24 h from cells grown in biofilm. The results of the study showed that Manuka honey significantly reduced cell viability in biofilm.
Manuka honey downregulated the genes encoding laminin, elastin, and fibrinogen binding protein involved in biosynthesis of polysaccharide intercellular adhesin in both strains.
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