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Markers of microbial exposure lower the incidence of atopic dermatitis

Markers of microbial exposure lower the incidence of atopic dermatitis

Researchers conducted a matched case-control study on incident atopic dermatitis (AD). Cases involved 426 outpatient children with a first diagnosed incident of atopic dermatitis. Controls were 426 children attending a pediatric/dermatological visit for non-atopic disorders.

The odds radio of first occurrence of atopic dermatiis was 0.35 for children who had experienced more than four infections compared with those with no infections.

A decreasing trend in risk was observed with increasing number of siblings, the protective effect reaching about 40% for children with 2 or more siblings.

Pet keeping, in particular daily contact with dogs, was inversely associated with atopic dermatitis risk.

These results suggest that early-life environmental exposures, including pathogens and commensals, act as "microbes contact carriers" influencing immune system balance early in life.

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Markers of microbial exposure lower the incidence of atopic dermatitis

Evidence of Ebola virus exposure in dogs in Liberia

Evidence of Ebola virus exposure in dogs in Liberia

Paradoxes of the brachycephalic dog-owner relationship

Paradoxes of the brachycephalic dog-owner relationship