Hi.

Welcome to my blog. I document my adventures in travel, style, and food. Hope you have a nice stay!

Acetaminophen Studied in Horses

Acetaminophen Studied in Horses

A study investigated the pharmacokinetic of acetaminophen dosed at 20 mg/kg in horses.  Eight healthy Thoroughbred geldings were given acetaminophen (20 mg/kg; 500 mg tablets) orally as a single dose followed by doses every 12 hours for 14 days. Only one dose level (20 mg/kg) was studied, sample size was small and only a single breed and sex was used, with no pre-treatment liver biopsies.

 

Serial blood samples were collected for determination of plasma acetaminophen concentrations using HPLC-UV. Serum biochemical analysis, gastroscopy, and liver biopsy were examined during the safety study. Following a single dose, mean maximum concentration was 16.61 μg/mL at 1.35 hours, and drug concentration was below the lower limit of detection in most horses by 24 hours. Elimination half-life was 2.78 h. No significant accumulation was noted following multiple doses. Average maximum concentration of acetaminophen following multiple oral dosing was 15.85 μg/mL and elimination half-life of 4 hours. Serum activities of sorbitol dehydrogenase were significantly decreased, and total bilirubin concentrations were significantly increased following the last dose. No statistically significant changes were noted in gastroscopy scores.

Read the link below for more information:

Pharmacokinetics and safety of repeated oral dosing of acetaminophen in adult horses.

 

Study Shows Recovered Horses May Be Silent Carriers

Study Shows Recovered Horses May Be Silent Carriers

Hills Expands Pet Food Recall

Hills Expands Pet Food Recall