Correlation Between Synovial Fluid Concentrations in Osteoarthritis
The relationship between synovial biomarker concentrations and severity of lameness and to assess the ability to differentiate normal from osteoarthritic joints with synovial biomarker concentrations was evaluated. The study evaluated twelve dogs with no evidence of osteoarthritis and 27 client-owned dogs with unilateral lameness and joint pain in a single joint from naturally occurring osteoarthritis.
Concentrations of monocyte chemoattractant protein (MCP)-1, substance P, interleukin (IL)-6, IL-8, KC-like, matrix metalloproteinase (MMP)-1, and MMP-3 were greater in dogs with osteoarthritis than in normal joints. The concentrations of bradykinin and tissue inhibitors of metalloproteinase-4 were decreased in osteoarthritis when compared with normal joints. There was no correlation between any biomarker concentration and severity of gait asymmetry at the walk.
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