Compatibility of dog erythrocyte antigen in domestic dog and non domesticated canines
The dog erythrocyte antigen (DEA) 1 has been considered the most clinical immunogenic and clinically important blood group in dogs.
In a study of 140 nondomesticated canids, blood samples were typed using two methods: immunochromatographic and flow cytometric techniques. The results showed that 72.9% were DEA 1+ and 27.1% were DEA 1− using immunochromatographic technique and 74.3% were DEA 1+ and 25.7% were DEA 1− by flow cytometric technique. The Crossmatch results between 140 nondomesticated canid red blood cells (RBCs) and plasma showed 80% incompatibilities. Also, the Crossmatches between 130 nondomesticated canid serum and 1 or up to 8 donor dogs' RBCs revealed 76% compatibilities while crossmatches between 115 nondomesticated canid RBCs and donor dogs' serum reported 51% compatibilities.
Most of the tested nondomesticated canids appear not to have alloantibodies against domestic dogs' RBCs. Cross-matching is crucial before xenotransfusion and it has been considered when specific blood types are not available.
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